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☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

Persons: Lawrence Faucette, Ann, he’d, ” Ann, Larry Faucette, Ann Faucette Ann, Larry, didn’t, ”, Robert Montgomery, “, Shelby Lum, ” Montgomery, Xenotransplantation, Art Caplan, Caplan, Babe ”, ” Caplan, They’re, eGenesis, people’s, Dr, Mike Curtis, Sanjay Gupta, ” Curtis, hasn’t, Julie O’Hara, Jim Parsons, Jayme Locke, couldn’t, Locke, Parsons, NYU —, Montgomery —, O’Hara, ” Locke, David Bennett Sr, Mary, David Jr, Bartley Griffith, Bennett, they’ve, Muhammad M, Mohiuddin, Larry Faucette’s, David Bennett’s, ” Griffith, xenotransplantation Ann Faucette, Wilbur, White’s, Ann Faucette, NYU ethicist Caplan, they’re, NYU’s Montgomery, UAB’s Locke, Steve Wood, ’ Curtis, “ I’m, it’s, ” O’Hara, Bennett’s, Larry Faucette —, ” Bennett’s, Faucette, who’d, Griffith, would’ve, Kate, Lucy, Nadia Kounang Organizations: CNN, Food and Drug Administration, University of Maryland, FDA, National Institute of Allergy, NYU Langone Transplant Institute, NYU Langone's Transplant, NYU Grossman School, Medicine’s Department of Population Health, “ Disney, University of Alabama, Transplant Institute, Parsons Family, Birmingham, NYU, University of Maryland School of Medicine, Doctors, University of Maryland Medical Center, Uno, UAB, CNN Health, NFL Locations: Frederick , Maryland, United States, Montgomery, “, Midwest, Yucatan, Maryland

☆ Drug study brings animal-to-human organ transplants a step closer, scientists say
▼ + stars: | 2024-01-25 | by ( Jen Christensen | ) edition.cnn.com time to read: +4 min

CNN —Scientists say they are closer to understanding the best way to make the human body receptive to an organ donation from another species, an effort that could help solve an ongoing shortage of organs. More than 100,000 people in the US are on the transplant waiting list, and an average of 17 die every day while waiting. Doctors have spent decades experimenting with alternatives, and many now see potential in replacing failing human organs with genetically modified pig organs. Xenotransplantation, as cross-species organ transplantation is called, is still in the early stages. There are no human clinical trials taking place that have been approved by the US Food and Drug Administration, but the researchers behind a study published Thursday in the Journal of Clinical Investigation say their findings might bring human trials even closer.

Persons: Jayme Locke, Locke, that’s, Sheri Krams, ”, Krams, Dr, Sanjay Gupta, Mandy Ford, Ford, ” Ford Organizations: CNN —, US Food and Drug Administration, Investigation, University of Alabama, Heersink, of Medicine, FDA, Transplantation, Heersink School of Medicine, Stanford Medicine, UAB, Parsons Model, CNN, CNN Health, Emory Transplant Center Locations: United States

☆ Surgeons Improve Function of Kidneys Transplanted From Genetically Altered Pigs
▼ + stars: | 2023-08-16 | by ( Roni Caryn Rabin | ) www.nytimes.com time to read: +3 min

A number of studies last year demonstrated that pig kidneys that had been transplanted into brain-dead individuals made urine, an essential function, for short periods of time. “The really new finding here is that these pig kidneys can clear enough creatinine to support an adult human,” Dr. Locke said. “If you want to have life-sustaining kidney function, the kidneys have to do more than just make urine,” Dr. Locke said. A few months later, researchers at the University of Maryland transplanted a heart from a genetically modified pig into a 57-year-old patient with heart failure. So far, transplants of genetically modified pig kidneys have been made only to brain-dead patients.

Persons: ”, Jayme Locke, Dr, Locke Organizations: Transplant Institute, NYU Langone Health, University of Maryland, Revivicor, United Therapeutics Corporation, Langone Health, Food and Drug Administration Locations: Alabama, New York

☆ Two research teams detail advancements in transplanting pig kidneys to humans, marking key steps on path to clinical trials
▼ + stars: | 2023-08-16 | by ( Deidre Mcphillips | ) edition.cnn.com time to read: +5 min

CNN —New advancements in transplanting pig kidneys to humans, detailed by two separate research teams on Wednesday, mark key steps forward in the evolving field of xenotransplantation, the use of non-human tissues or organs to treat medical conditions in humans. Both research teams used genetically modified pig kidneys that were transplanted into recipients experiencing brain death in what is considered pre-clinical human research. Other studies have demonstrated that this can occur when pig kidneys are transplanted in non-human primates. The team has been monitoring pig kidney transplants in a brain-dead decedent – a man named Maurice Miller, known as Mo, who died of a brain tumor – for nearly two months. “Over the last 20 years, we’ve gained a lot of information about how pig kidneys work to replace the functions in primates.

Persons: ”, Jayme Locke, Locke, ” Locke, NYU Langone, Maurice Miller, Mo, Robert Montgomery, Dr, Sanjay Gupta, “ We’re, Adam Griesemer, we’ve, ’ –, we’re Organizations: CNN, University of Alabama, Birmingham Heersink School of Medicine, New York University, Health, Comprehensive Transplant Institute, ”, UAB, NYU, NYU Langone Transplant Institute, CNN Health, Liver Transplant, FDA, US Department of Health, Human, Transplantation Network

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